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KMID : 0620720190250010072
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Natural Product Sciences
2019 Volume.25 No. 1 p.72 ~ p.75
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Cytotoxic Constituents from the Roots of Asarum sieboldii in Human Breast Cancer Cells
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Kim Eun-Ae
Kim Hyun-Jung
Oh Ha-Na
Kwak Ah-Won
Kim Su-Nam
Kang Bok-Yun
Cho Seung-Sik
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Abstract
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Bioassay-guided fractionation of the roots of Asarum sieboldii led to the isolation of the six compounds methylkakuol (1), sesamin (2), asarinin (3), xanthoxylol (4), and (2E,4E,8Z,10E/Z)-N-(2-methylpropyl) dodeca-2,4,8,10-tetraenamide (5/6). Among the isolates, xanthoxylol (4) exhibited significant cytotoxicity against human breast cancer cells MCF-7 and MDA-MB-231 in vitro with IC50 values of 9.15 and 13.95 μM, respectively.
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KEYWORD
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Asarum sieboldii, Cytotoxicity, Breast cancer, Xanthoxylol
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