KMID : 0620720190250030228
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Natural Product Sciences 2019 Volume.25 No. 3 p.228 ~ p.232
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Xylaroisopimaranin A, a New Isopimarane Derivative from an Endophytic Fungus Xylaralyce sp
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Bao Shang-Song
Liu Hui-Hui Zhang Xue-Qing Liu Cheng-Xiong Li Xiao-Cong Guo Zhi-Yong
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Abstract
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Five secondary metabolites, including a new isopimarane derivative xylaroisopimaranin A (1), were isolated from the endophytic fungus Xylaralyce sp. (HM-1), and their structures were elucidated by 1D, 2D NMR, MS and CD spectra. Their bioactivities were performed to antibacterial, Hep G2 cells cytotoxicity and brine shrimp inhibition. The biological evaluation results showed that the xylaroisopimaranin A (1), xylabisboein B (2), griseofulvin (3) , 5-methylmellein (4) and mellein-5-carboxlic acid (5) displayed no significant Hep G2 cells cytotoxicity and antibacterial acitivity, but they inhibited the brine shrimp with IC50 from 0.5 to 25 ¥ìmol/mL.
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KEYWORD
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Endophytic fungus, Xylaralyce sp., Structural elucidation, Brine shrimp inhibition
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