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KMID : 0620720190250030244
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Natural Product Sciences
2019 Volume.25 No. 3 p.244 ~ p.247
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Flavestin K, An Isoprenylated Stilbene from the Leaves of Macaranga recurvata Gage
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Tjahjandarie Tjitjik Srie
Tanjung Mulyadi
Saputri Ratih Dewi
Nadar Puja Bintu
Aldin Muhammad Fajar
Marliana Eva
Permadi Anton
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Abstract
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A new isoprenylated stilbene, flavestinK (1) together with two known isoprenylated stilbenes, flavestin B (2), flavestin G (3), and two isoprenilated flavanones, 4-O-methyl-8-isoprenylnaringenin (4) and 8- isoprenyl-5,7-dihydroxyflavanone (5) were isolated from the leaves of Macaranga recurvata Gage. All of the structures have been determined based on HRESIMS, 1D and 2D NMR spectral data. All of the isolated compounds were evaluated for their cytotoxicity against three human cancer cells (HeLa, T47D and WiDr). Compound 1 showed higher activity than doxorubicin against HeLa cells with IC50 value of 13.1 μg/mL.
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KEYWORD
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Flavestin K, Stilbene, Macaranga recurvata, Cytotoxicity
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