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KMID : 0624620130460010001
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BMB Reports
2013 Volume.46 No. 1 p.1 ~ p.8
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Biochemistry and structure of phosphoinositide phosphatases
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Kim Young-Jun
Jahan Nusrat
Bahk Young-Yil
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Abstract
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Phosphoinositides are the phosphorylated derivatives of phosphatidylinositol, and play a very significant role in a diverse range of signaling processes in eukaryotic cells. A number of phosphoinositide-metabolizing enzymes, including phosphoinositide-kinases and phosphatases are involved in the synthesis and degradation of these phospholipids. Recently, the function of various phosphatases in the phosphatidylinositol signaling pathway has been of great interest. In the present review we summarize the structural insights and biochemistry of various phosphatases in regulating phosphoinositide metabolism.
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KEYWORD
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Phosphoinositide metabolism, Phosphoinositide phosphatases, Phosphoinositides, Signal transduction
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