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KMID : 0624620150480050283
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BMB Reports
2015 Volume.48 No. 5 p.283 ~ p.288
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Resveratrol regulates na?ve CD 8+ T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression
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Noh Kyung-Tae
Cho Joon
Chun Sung-Hak
Jang Jong-Hwa
Cha Gil-Sun
Jung In-Duk
Jang Dong-Deuk
Park Yeong-Min
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Abstract
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We found that resveratrol enhances interferon (IFN)-?-induced tryptophanyl-tRNA-synthetase (TTS) expression in bone marrow- derived dendritic cells (BMDCs). Resveratrol-induced TTS expression is associated with glycogen synthase kinase-3? (GSK-3?) activity. In addition, we found that resveratrol regulates na?ve CD8+ T-cell polarization by modulating GSK-3? activity in IFN-?-stimulated BMDCs, and that resveratol induces upregulation of TTS in CD8+ T-cells in the in vivo tumor environment. Taken together, resveratrol upregulates IFN-?-induced TTS expression in a GSK-3?-dependent manner, and this TTS modulation is crucial for DC-mediated T-cell modulation.
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KEYWORD
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Bone marrow-derived dendritic cells, CD8+ T cell, Glycogen synthase kinase 3, Resveratrol, Tryptophanyl-tRNA synthetase
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