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KMID : 0624620160490080403
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BMB Reports
2016 Volume.49 No. 8 p.403 ~ p.404
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Mechanosensitive β-catenin signaling regulates lymphatic vascular development
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Cha Bok-Sik
Srinivasan R. Sathish
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Abstract
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The Wnt/β-catenin signaling is an evolutionarily conserved pathway that plays a pivotal role in embryonic development and adult homeostasis. However, we have limited information about the involvement of Wnt/β-catenin signaling in the lymphatic vascular system that regulates fluid homeostasis by absorbing interstitial fluid and returning it to blood circulation. In this recent publication we report that canonical Wnt/β-catenin signaling is highly active and critical for the formation of lymphovenus valves (LVVs) and lymphatic valves (LVs). β-catenin directly associates with the regulatory elements of the lymphedema-associated transcription factor, FOXC2 and activates its expression in an oscillatory shear stress (OSS)-dependent manner. The phenotype of β-catenin null embryos was rescued by FOXC2 overexpression. These results suggest that Wnt/β-catenin signaling is a mechanotransducer that links fluid force with lymphatic vascular development.
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KEYWORD
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FOXC2, Lymphatic valves, Lymphovenous valves, Wnt/ β-catenin
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