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KMID : 0624620200530100512
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BMB Reports
2020 Volume.53 No. 10 p.512 ~ p.520
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A new aspect of an old friend: the beneficial effect of metformin on anti-tumor immunity
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Kim Kyeong-Jin
Yang Wen-Hao
Jung Youn-Sang
Cha Jong-Ho
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Abstract
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T-cell-based cancer immunotherapies, such as immune checkpoint blockers (ICBs) and chimeric antigen receptor (CAR)-Tcells, have significant anti-tumor effects against certain types of cancer, providing a new paradigm for cancer treatment. However, the activity of tumor infiltrating T-cells (TILs) can be effectively neutralized in the tumor microenvironment (TME) of most solid tumors, rich in various immunosuppressive factors and cells. Therefore, to improve the clinical outcomes of established T-cell-based immunotherapy, adjuvants that can comprehensively relieve multiple immunosuppressive mechanisms of TME are needed. In this regard, recent studies have revealed that metformin has several beneficial effects on anti-tumor immunity. In this mini-review, we understand the immunosuppressive properties of TME and how metformin comprehensively enhances anti-tumor immunity. Finally, we will discuss this old friend's potential as an adjuvant for cancer immunotherapy.
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KEYWORD
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Adjuvant, Cancer immunotherapy, Cold tumor and tumor microenvironment, Metformin
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