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KMID : 0644120180310020018
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Journal of Oriental Gynecology
2018 Volume.31 No. 2 p.18 ~ p.30
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Effects of Artemisiae Annuae Herba (AAH) on Cell Death of Ovarian Cancer in Vivo and in Vitro Study
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Seo Kook-Jang
Jo Sung-Hee
Yang Seung-Jung
Park Kyung-Mi
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Abstract
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Objective: This study was designed to investigate the anti-cancer effects of AAH on ovarian cancer in vitro and by using allograft model in vivo.
Methods: In this experiment, the effects of AAH on proliferation rates, cell morphology, cell death type, cell cycle, caspase activities and p38 mitogen-activated protein kinase (MAPK) pathway were investigated in A2780, human ovarian cell line.
Results: AAH inhibited proliferation of A2780 cells in a dose dependent manner. In addition, AAH induced apoptosis but did not affect cell cycle of A2780 cells. AAH also effectively inhibited caspase 3 and caspase 9 activities respectively. In allograft tumor model, AAH reduced tumor volume and expanded life span in a dose dependent manner.
Conclusion: It can be inferred that AAH can induce apoptosis in ovarian cancer cells and has possibility as an anticancer agent for ovarian cancer.
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KEYWORD
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Artemisiae Annuae Herba , Ovarian Cancer , Apoptosis , p38 MAPK , Caspase 3 , Caspase 6
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