|
KMID : 0644120180310020049
|
|
Journal of Oriental Gynecology
2018 Volume.31 No. 2 p.49 ~ p.67
|
|
|
Effects of Hwanggimacmundong-tang on Body Weight and Gene Expression in Obese Rats with Estrogen Deficiency
|
|
Lee Hye-In
Yoo Dong-Youl
Yoo Jeong-Eun
|
|
|
Abstract
|
|
|
Objectives: This study was conducted to assess the effects of Hwanggimacmundong-tang extract (HM) on obese rats with estrogen deficiency.
Methods: The experiments were performed with ovariectomized rats as estrogen-deficient obesity model. Rats were grouped NC (Normal Control Group; sham operation group), OC (Obesity Control Group; estrogen-deficient group), HML (20 mg/kg/day), HMH (100 mg/kg/day). HM was administered orally for six weeks. Body weights and serum lipid level were measured, and real-time PCR was performed to estimate the effect of HM on gene expression in liver.
Results: HM decreased the total cholesterol and triglyceride in serum. And HM increased leptin, CPT1 gene expression in liver tissue of obese rats with estrogen deficiency. However HM decreased PPARγ, PGC-1α, HMGCR, CYP8B1, LPL,
ACAT1, ACAT2, ApoB, ACOX gene expression in liver tissue of obese rats with estrogen deficiency.
Conclusions: It is concluded that HM reduced total cholesterol and triglyceride in serum, and regulate gene expression related to lipid metabolism. These results indicate Hwanggimacmundong-tang that might have potential for treatment of obesity and complications during the menopause caused by estrogen-deficiency.
|
|
|
KEYWORD
|
|
|
Hwanggimacmundong-tang , Obesity , Menopause , Estrogen-deficiency , Gene Expression
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|