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KMID : 0644120210340030001
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Journal of Oriental Gynecology
2021 Volume.34 No. 3 p.1 ~ p.14
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A Study on the Regulation of Endometrial and Placental Cell Function by 3 Types of Herbal Medicines and Scutellariae Radix
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Park Seo-Ye
Noh Eui-Jeong
Seo Chang-Seob
Lee Sung-Ki
Shin Hyeun-Kyoo
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Abstract
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Methods: We investigated the ability to induce decidualization of human endometrial stromal cells and invasive ability of human trophoblast cells by water extract of three types herbal medicines (Dangguijakyak-san, Siryung-tang, Antae-eum) and ethanol extract on Scutellariae Radix.
Results: In the process of decidualization of endometrial stromal cells, three herbal medicines including Dangguijakyak-san, Siryung-tang, and Scutellariae Radix increased the production of decidual markers such as prolactin (PRL) and insulin-like growth factor-binding protein 1 (IGFBP1). However, Antae-eum increased mRNA levels of PRL and IGFBP and secretion of IGFBP in decidual stromal cells, but not PRL. Four herbal medicines inhibited the invasion of trophoblast cells.
Conclusions: Four herbal medicines may play a role in implantation in women with reproductive failures. However, further studies are warranted to elucidate whether these medications are helpful in the maintenance of pregnancy.
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KEYWORD
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Endometrial Stromal Cell, Decidualization, Trophoblast, Invasion, Herbal Medicines, Dangguijakyak-san, Siryung-tang, Antae-eum, Scutellariae Radix
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