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KMID : 0644120210340040001
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Journal of Oriental Gynecology
2021 Volume.34 No. 4 p.1 ~ p.11
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Renoprotective effect of Maydis Stigma on Puromycin Aminonucleoside-induced Nephrotic Syndrome
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Yoon Jung-Joo
Kho Min-Chol
Han Byung-Hyuk
Kim Hye-Yoom
Ahn You-Mee
Lee Yun-Jung
Lee Ho-Sub
Kang Dae-Gill
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Abstract
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Objectives: Nephrotic syndrome is a kidney disorder, which is characterized by proteinuria, edema (swelling), and hyperlipidemia. Maydis Stigma (Corn silk) has been widely used in Asia as a traditional medicine and is known to have a diuretic effect and is used for the treatment of edema and indigestion.
Methods: The aim of this study is to investigate the improvement effect of Maydis Stigma in treating nephrotic syndrome induced by puromycin aminonucleoside. Sprague-Dawley rats were intravenously injected with 75 mg/kg/day puromycin aminonucleoside, then treated with either Losartan or 200 mg/kg/day Maydis Stigma for seven days.
Results: Maydis Stigma significantly decreased ascites and proteinuria level. Plasma levels of blood urea nitrogen (BUN) and plasma creatinine reduced significantly by Maydis Stigma. In addition, treatment with Maydis Stigma attenuated histological damage. Treatment with Maydis Stigma also restored podocin expression and reduced inflammation markers such as intracellular adhesion molecules (ICAM-1), monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor alpha (TNF-α) and high-mobility group box-1 (HMGB1).
Conclusions: Maydis Stigma ameliorates kidney injury in nephrotic syndrome rat models. Maydis Stigma exerts a renoprotective effect owing to its anti-inflammatory effects and reductions of ascites and proteinuria. Thus, these results indicate that Maydis Stigma is likely to be a promising agent in the treatment of nephrotic syndrome.
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KEYWORD
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Nephrotic syndrome, Maydis Stigma, Ascites, Proteinuria, Inflammation
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