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KMID : 0665220210340060568
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Korean Journal of Food and Nutrition
2021 Volume.34 No. 6 p.568 ~ p.575
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Cynanchum wilfordii and Phlomis umbrosa Extract (IPLUS-CWPU) Stimulated Bone Growth and Differentiation by Enhancing Growth-Related Factors in Young Sprague Dawley Rats
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Song Hye-Jin
Seo Yoon-Hee
Hong Sang-Keun
Choe Soo-Young
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Abstract
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The purpose of this study was to investigate the effects of extract mixture of C. wilfordii and P. umbrosa (IPLUS-CWPU) on bone growth in 4-week old young male SD rats. To confirm the effect of IPLUS-CWPU, we measured the length of bone growth plate, the ratio of proliferative zone to the length of growth plate and the expression level of insulin-like growth factor, IGF-1. The IPLUS-CWPU treatment shows a significant increase of tibial and femoral growth plate and the ratio of proliferative zone in growth plate. Especially, the length increased by 13.9% and 25.3% in the tibia and femur, respectively, in the high-dose group compared to the normal group. Moreover, the expression of IGF-1 gene in liver was upregulated in IPLUS-CWPU treated groups. These results indicated that IPLUS-CWPU administration could increase the proliferative zone of bone growth plate in early developmental stage by upregulation of IGF-1 gene.
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KEYWORD
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Cynanchum wilfordii, Phlomis umbrosa, growth plate, bone differentiation, proliferative zone, insulin like growth factor-1
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