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KMID : 0811720010050000171
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Korean Journal of Physiology & Pharmacology
2001 Volume.5 No. 0 p.171 ~ p.0
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Ascending Routes of Nerve-Injury Induced Mechanical Allodynia in a Rat Model
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Back Seung-Keun
Na Heung-Sik
Kim June-Sun
Hong Seung-Kil
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Abstract
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The ascending pathways of input signals mediating mechanical allodynia after peripheral nerve injury remain uncertain. This study examined whether or not the dorsal column is a unique pathway to transmit the signals for the induction and maintenance of mechanical allodynia. To this aim, we compared the effects of ipsilateral dorsal column (DC) lesion performed before and after peripheral nerve injury on mechanical allodynia signs (i.e., tail withdrawal response), which was elicited by innocuous von Frey hair (19.6 mN, 2.0 g) stimulation to the tail after a unilateral transection of the superior and inferior caudal trunks at the level between the S1 and S2 spinal nerves. Interruption of the ipsilateral DC pathway was performed at the level of T13 just prior to or 2 weeks after neuropathic surgery. The ipsilateral DC lesion at 2 weeks after neuropathic surgery significantly, but not completely, relieved mechanical allodynia. In addition, the ipsilateral DC lesion prior to neuropathic surgery did not prevent the induction of mechanical allodynia. These results suggest that the induction and maintenance of mechanical allodynia following peripheral nerve injury involve transmission of the sensory signal to supraspinal loci via the ipsilateral DC and another pathways.
Source: Korean J Physiol Pharmacol.2001 Dec;5(Suppl II):S96-S97
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