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KMID : 0811720060100000332
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Korean Journal of Physiology & Pharmacology
2006 Volume.10 No. 0 p.332 ~ p.0
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EFFECTS OF EXERCISE ON ACTIVATION OF EXTRACELLULAR SIGNAL-REGULATED KINASES AND C-JUN N-TERMINAL KINASE PATHWAYS IN RAT TIBIALIS MUSCLE
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Park Han-Su
Choi Suck-Jun
Lee Jae-Hee
Kim Min-Sun
Chae Jeong-Rowing
Park Byung-Rim
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Abstract
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The effect of either low- or moderate-to-high-intensity four weeks exercise treadmill running on the activation of the
extracellular-signal regulated protein kinase (ERK1/2) and the c-Jun N-terminal kinase(JNK) pathways was determined
in rat muscle. Sprague-Dawley rats were assigned to one of three groups: (i) sedentary group(NE; n=10); (ii) low-intensity
exercise group (8m/min; LIE; n=10); and (iii) moderate-to -high-intensity exercise group(28m/min; HIE; n=10). The training regimens were planned so that animals covered the same distance and had similar glycogen utilization for both LIE and HIE exercise sessions. After four weeks exercise, 48 h after the last exercise bout obtained samples. pERK1 increased 1.5 times conparing with the sedentary group in the low intensity group while it increased 11.7 times in moderate-to -high-intensity group, in the tibialis of rats. In the low intensity group, pERK2 increased 1.4 times comparing with the sedentary group while it increased 3.3 times in moderate-to-high-intensity group. While pJNK1 decreased 0.9 times, comparing with the sedentary group, pJNK2 was increased to 0.5 times in the low intensity group. But in moderate-to -high-intensity group, pJNK2 decreased 0.7 times while pJNK1 didn`t show any change. In conclusion, Four weeks exercise of different intensities results in tibialis muscle activation of intracellular signal pathways, which may be one mechanism regulating specific adaptations induced by different exercise intensities.
Source: Korean J Physiol Pharmacol.2006 Oct;10(Suppl II):242
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KEYWORD
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Tibialis, ERK, JNK
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