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KMID : 0811720130170020111
Korean Journal of Physiology & Pharmacology
2013 Volume.17 No. 2 p.111 ~ p.120
Prolyl 4 Hydroxylase: A Critical Target in the Pathophysiology of Diseases
Ravi Kant

Anjana Bali
Nirmal Singh
Amteshwar Singh Jaggi
Abstract
Prolyl 4 hydroxylases (P4H) are iron- and 2-oxoglutamate-dependent dioxygenase enzymes and hypoxia-inducible transcription factor (HIF)-P4Hs play a critical role in the regulating oxygen homeostasis in the local tissues as well in the systemic circulation. Over a period of time, a number of prolyl hydroxylase inhibitors and activators have been developed. By employing the pharmacological tools and transgenic knock out animals, the critical role of these enzymes has been established in the pathophysiology of number of diseases including myocardial infarction, congestive heart failure, stroke, neurodegeneration, inflammatory disease, respiratory diseases, retinopathy and others. The present review discusses the different aspects of these enzymes including their pathophysiological role in disease development.
KEYWORD
Hypoxia inducible factor, Inflammation, Ischemia, Prolyl hydroxylase
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