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KMID : 0811720150190010021
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Korean Journal of Physiology & Pharmacology
2015 Volume.19 No. 1 p.21 ~ p.28
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Anti-inflammatory, Antioxidant and Antimicrobial Effects of Artemisinin Extracts from Artemisia annua L.
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Kim Wan-Su
Choi Woo-Jin
Lee Sun-woo
Kim Woo-Joong
Lee Dong-Chae
Sohn Uy-Dong
Shin Hyoung-Shik
Kim Won-Yong
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Abstract
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The anti-inflammatory, antioxidant, and antimicrobial properties of artemisinin derived from water, methanol, ethanol, or acetone extracts of Artemisia annua L. were evaluated. All 4 artemisinin- containing extracts had anti-inflammatory effects. Of these, the acetone extract had the greatest inhibitory effect on lipopolysaccharide-induced nitric oxide (NO), prostaglandin E2 (PGE2), and pro- inflammatory cytokine (IL-1β, IL-6, and IL-10) production. Antioxidant activity evaluations revealed that the ethanol extract had the highest free radical scavenging activity, (91.0±3.2%), similar to α- tocopherol (99.9%). The extracts had antimicrobial activity against the periodontopathic micro-organisms Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum subsp. animalis, Fuso-bacterium nucleatum subsp. polymorphum, and Prevotella intermedia. This study shows that Artemisia annua L. extracts contain anti-inflammatory, antioxidant, and antimicrobial substances and should be considered for use in pharmaceutical products for the treatment of dental diseases.
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KEYWORD
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Anti-inflammatory effect, Anti-microbial activity, Antioxidant activity, Artemisinin
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