KMID : 0811720150190060479
|
|
Korean Journal of Physiology & Pharmacology 2015 Volume.19 No. 6 p.479 ~ p.484
|
|
Role of Nucleotide-binding and Oligomerization Domain 2 Protein (NOD2) in the Development of Atherosclerosis
|
|
Kim Ha-Jeong
|
|
Abstract
|
|
|
NOD2 (nucleotide-binding and oligomerization domain 2) was initially reported as a susceptibility gene for Crohn¡¯s disease, with several studies focused on elucidating its molecular mechanism in the progression of Crohn¡¯s disease. We now know that NOD2 is an intracellular bacterial sensing receptor, and that MDP-mediated NOD2 activation drives inflammatory signaling. Various mutations in NOD2 have been reported, with NOD2 loss of function being associated with the development of Crohn¡¯s disease and other autoimmune diseases. These results suggest that NOD2 not only has an immune stimulatory function, but also an immune regulatory function. Atherosclerosis is a chronic inflammatory disease of the arterial wall; its pathologic progression is highly dependent on the immune balance. This immune balance is regulated by infiltrating monocytes and macrophages, both of which express NOD2. These findings indicate a potential role of NOD2 in atherosclerosis. The purpose of this review is to outline the known roles of NOD2 signaling in the pathogenesis of atherosclerosis.
|
|
KEYWORD
|
|
Atherosclerosis, Chronic inflammatory disease, Immune balance, NOD2
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|