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KMID : 0811720170210060651
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Korean Journal of Physiology & Pharmacology
2017 Volume.21 No. 6 p.651 ~ p.656
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Ursolic acid supplementation decreases markers of skeletal muscle damage during resistance training in resistance-trained men: a pilot study
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Bang Hyun-Seok
Seo Dae-Yun
Chung Young-Min
Kim Do-Hyung
Lee Sam-Jun
Lee Sung-Ryul
Kwak Hyo-Bum
Kim Tae-Nyun
Kim Min
Oh Kyoung-Mo
Son Young-Jin
Kim Sang-Hyun
Han Jin
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Abstract
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Ursolic acid (UA) supplementation was previously shown to improve skeletal muscle function in resistance-trained men. This study aimed to determine, using the same experimental paradigm, whether UA also has beneficial effects on exercise-induced skeletal muscle damage markers including the levels of cortisol, B-type natriuretic peptide (BNP), myoglobin, creatine kinase (CK), creatine kinase-myocardial band (CK-MB), and lactate dehydrogenase (LDH) in resistance-trained men. Sixteen healthy participants were randomly assigned to resistance training (RT) or RT+UA groups (n=8 per group). Participants were trained according to the RT program (60~80% of 1 repetition, 6 times/week), and the UA group was additionally given UA supplementation (450 mg/day) for 8 weeks. Blood samples were obtained before and after intervention, and cortisol, BNP, myoglobin, CK, CK-MB, and LDH levels were analyzed. Subjects who underwent RT alone showed no significant change in body composition and markers of skeletal muscle damage, whereas RT+UA group showed slightly decreased body weight and body fat percentage and slightly increased lean body mass, but without statistical significance. In addition, UA supplementation significantly decreased the BNP, CK, CK-MB, and LDH levels (p<0.05). In conclusion, UA supplementation alleviates increased skeletal muscle damage markers after RT. This finding provides evidence for a potential new therapy for resistance-trained men.
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KEYWORD
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Resistance training, Resistance-trained men, Skeletal muscle damage markers, Ursolic acid
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