Àá½Ã¸¸ ±â´Ù·Á ÁÖ¼¼¿ä. ·ÎµùÁßÀÔ´Ï´Ù.
KMID : 0811720230270040357
Korean Journal of Physiology & Pharmacology
2023 Volume.27 No. 4 p.357 ~ p.364
Shikonin ameliorates salivary gland damage and inflammation in a mouse model of Sjogren¡¯s syndrome by modulating MAPK signaling pathway
Wenjing Guo

Cho Sung-Bum
Chao Sun
Jian Wang
Tao Wang
Abstract
Sjogren syndrome (SS) is a systemic inflammatory autoimmune disease that involves exocrine glands. Shikonin is extracted from comfrey, which is conventionally used as an anti-tumor, antibacterial, and antiviral drug in China. However, the application of Shikonin in SS remains unreported. This study aimed to verify the potential functions of Shikonin in SS progression. Firstly, non-obese diabetic mice were used as the SS mouse model, with C57BL/6 mice serving as the healthy control. It was demonstrated that the salivary gland damage and inflammation were aggravated in the SS mouse model. Shikonin improved salivary gland function decline and injury in the SS mouse model. Moreover, Shikonin reduced inflammatory cytokines and immune infiltration in the SS mouse model. Further experiments discovered that Shikonin attenuated the MAPK signaling pathway in the SS mouse model. Lastly, inhibition of the MAPK signaling pathway combined with Shikonin treatment further alleviated the symptoms of SS. In conclusion, Shikonin ameliorated salivary gland damage and inflammation in a mouse model of SS by modulating the MAPK signaling pathway. Our findings indicate that Shikonin may be a useful drug for SS treatment.
KEYWORD
Inflammation, Salivary gland, Shikonin, Sjogren¡¯s syndrome
FullTexts / Linksout information
 
Listed journal information