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KMID : 0829320060090010018
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Korean Journal of Clinical Microbiology
2006 Volume.9 No. 1 p.18 ~ p.23
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Association of T Antigens with emm Genotypes of Group A Streptococci
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Jung Hyun-Ju
Koh Eun-Ha
Kim Sun-Joo
Maeng Kook-Young
Kang Sung-Ha
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Abstract
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Background: T typing has been used as a screening test for epidemiologic studies of group A streptococci (GAS) infections or carriers, and M typing has been performed for virulence studies. However, M typing is difficult to perform in routine laboratories. Recently, genotyping of the emm gene, which encodes the M protein, has become available. We investigated which T antigen is closely associated with a certain emm genotype.
Methods: GAS were collected from the children in Jinju who were asymptomatic carriers (N=349) or had acute pharyngitis (N=122) during the 3 year-period from 2002 through 2004. T typing was performed by a slide aggulutination, and emm genotyping by PCR and DNA sequencing.
Results: More than 90% of T1, T3, T6, T12, T25, and T5/27/44 antigens were associated with emm1, emm3, emm6, emm12 and 22, emm75, and emm44/61 genotypes, respectively; however, other T antigens, such as T2, T4, T7, T11, and B3264, were not associated with any particular emm genotypes.
Conclusion: Several T antigens are so closely associated with particular emm genotypes that one could predict emm genotypes based on the result of T typing. (Korean J Clin Microbiol 2006;9(1):18-23)
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KEYWORD
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Group A streptococci, Streptococcus pyogenes, T antigen, emm genotype, Epidemiology, Pharyngitis
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