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KMID : 0854720070270020105
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Korean Journal of Asthma, Allergy and Clinical Immunology
2007 Volume.27 No. 2 p.105 ~ p.110
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Airway Hyperresponsiveness-related Aeroallergens in Suspected Asthma
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Han Eui-Ryoung
Choi In-Seon
Lee Suk
Cho Young-Wook
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Abstract
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Background: House dust mites and cats are major allergens causing asthma, and grass pollens are more closely related to allergic rhinitis. Objective: To investigate which aeroallergens are related to airway hyperresponsiveness (AHR), a characteristic feature of asthma, in Korean patients.
Method: Medical records of suspected asthmatics, who performed both skin prick tests using common aeroallergens and the methacholine bronchoprovocation test between 2001 and 2007, were reviewed. A positive response to an allergen was defined as allergen/histamine wheal ratio of ≥1. A positive and a ≥moderate AHR were defined as 20% fall in FEV1 to ≤25 and ≤2 mg/mL of methacholine, respectively. The relative risks (adjusted odds ratio) for AHR compared to non-atopy were determined by a multivariate logistic regression analysis.
Result: House dust mites were the most prevalent allergens in both asthma (n=238) and non-asthma (n=149) patients. The AHR severity was significantly related to the sensitization rates to house dust mites in asthmatics. The relative risks for ≥moderate AHR of subjects sensitized to Dermatophagoides farinae and hazel were 1.21 (P＜0.01) and 0.72 (P＜0.05), respectively.
Conclusion: Sensitization to a house dust mite, D. farinae, might be a significant risk factor for AHR, but hazel sensitization was protective and might be related to allergic rhinitis. (Korean J Asthma Allergy Clin Immunol 2007; 27:105-110)
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KEYWORD
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Aeroallergen, Airway responsiveness, Asthma
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