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KMID : 0854720120320030193
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Korean Journal of Asthma, Allergy and Clinical Immunology
2012 Volume.32 No. 3 p.193 ~ p.197
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A Case of Churg-Strauss Syndrome with Acute Renal Failure
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Jeong Il-Hwan
Nam Young-Hee
Kim Dae-Chul
Lee Hye-Won
Yoon Neul-Bom
Um Soo-Jung
Lee Soo-Keol
Son Choon-Hee
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Abstract
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Background: Churg-Strauss syndrome is a rare systemic disorder characterized by bronchial asthma, hypereosinophilia and systemic vasculitis. The prevalence and severity of renal involvement in patients with Churg-Strauss syndrome is not well known. We report a rare case of a patient with Churg-Strauss syndrome accompanied by acute renal failure.
Case History: A 52-year-old woman with skin rash and generalized edema was admitted to our hospital via the
emergency room. She had a 7-year history of bronchial asthma and allergic rhinitis. Laboratory evaluation showed marked eosinophilia, elevated creatinine, and heavy proteinuria. She was positive for anti-neutrophil cytoplasmic antibody. Computed tomography of chest and paranasal sinuses revealed pulmonary infiltration and pansinusitis. Peripheral neuropathy was confirmed and small vasculitis was noted in a skin biopsy specimen.
Results: She was diagnosed with Churg-Strauss syndrome and showed rapidly progressive renal insufficiency despite systemic corticosteroid administration. Oilguria was aggravated, and hemodialysis was thereafter started. Despite
2 weeks of continuous hemodialysis, her renal function was not improved.
Conclusion: We report a rare case of Churg-Strauss syndrome associated with acute renal failure. A long-term follow-up is needed in Churg-Strauss syndrome patients.
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KEYWORD
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Churg-Strauss syndrome, Renal insufficiency, Vasculitis
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