KMID : 0855520140270020071
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Korean Journal of Physical Anthropology 2014 Volume.27 No. 2 p.71 ~ p.77
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Immunohistochemical Study of O-GlcNAcylation in Human Skin Tumors
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Lee Young
Hong Boo-Hwi Choi Dae-Kyoung Lim Seul-Ki Sohn Kyung-Cheol Im Myung Seo Young-Joon Lee Young-Ho Lee Jeung-Hoon Kim Chang-Deok
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Abstract
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O-linked ¥â-N-acetylglucosamine modification is an important post-translational modification, emerging as a novel regulatory mechanism in various cellular events. Recently, several studies have shown that O-GlcNAcylation plays an essential role in human breast, lung, and colon cancers. With regard to skin cancers, the role of O-GlcNAcylation has yet to be elucidated. To investigate whether O-GlcNAcylation is linked to human skin tumor development, immunohistochemical analysis was performed to investigate the presence of OGlcNAcylation in various skin tumors. We evaluated the levels of O-GlcNAcylation, O-GlcNAc transferase, and O-GlcNAcase in 29 benign tumors, 12 premalignant tumors, and 26 malignant tumors in skin. Compared to the benign tumors, premalignant and malignant tumors had increased patterns of O-GlcNAcylation. In addition, the O-GlcNAc transferase and O-GlcNAcase levels were higher in premalignant and malignant tumors than in benign tumors. Interestingly, O-GlcNAcase levels were significantly increased in premalignant tumors compared to benign and malignant tumors. These results suggest that O-GlcNAcylation of proteins may play an important role in the development of human skin tumors.
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KEYWORD
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Immunohistochemistry, O-GlcNAc, O-GlcNAcase, O-GlcNAc transferase, Skin neoplasm, O-GlcNAc, O-GlcNAcase, O-GlcNAc transferase
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