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KMID : 0870520140180010003
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Journal of Korean Academy of Addiction Psychiatry
2014 Volume.18 No. 1 p.3 ~ p.16
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What is Addiction ( I ) - Pathophysiology and Therapeutic Implications -
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Park Seo-Yeon
Kang Ung-Gu
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Abstract
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Addiction is a state where drug-seeking behavior is abnormally enhanced. A multitude of neurobiological mechanisms are involved in this state ; 1) allostasis, which is related to the tolerance and withdrawal 2) learning, which establishes the relationship between drug-related stimuli and the effect of drug 3) abnormal motivation, which is not attenuated by the consumption of the target object and 4) sensitization, where the biological effect of drug is enhanced during repetitive use. In this article, these mechanisms are briefly reviewed in terms of their relationship to the pathophysiology and treatment modalities of addiction.
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KEYWORD
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Addiction, Allostasis, Learning, ensitization, Motivation, Salience
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