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KMID : 08793200120010010052
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Annuals of Clinical Study - Seoul National Hospital
2001 Volume.2001 No. 1 p.52 ~ p.56
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Relationship between Clozapine Induced Therapeutic Responses and Plasma Homovanilic Acid Level in Patient with Schizophrenia
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한성희/Han SH
최성엽/이경덕/Choi SY/Lee KD
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Abstract
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Measurement of plasma concentrations of dopamine metabolite, homovanilic acid(pHVA), is indirect tool to assess changes in dopamine turnover. Levels of pHVA have been reported to decrease during treatment with conventional antidopaminergic, neroleptics, with the decrement correlating with symptomatic improvement in schizophrenic symptoms. Atypical neuroleptic clozapine has unusual profile if clinical effects and a distinctive spectrum of pharmacological actions and is the drug proved to effective in treatment-refractory patients. The mechanism mediating this efficacy has not been fully elucidated. This study examined the effect of clozapine on pHVA concentrations in schizophrenic patients. We obtained assessments of pHVA in twelve schizophrenic patients who were treated with clozapine for 4 weeks pHVA concentrations were not significantly changed during treatment with clozapine. This finding suggest that clozapine may be effective in schizophrenia by mechanism other than, or in addition to dopamine receptor blockade.
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KEYWORD
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