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KMID : 0880220070450010075
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Journal of Microbiology
2007 Volume.45 No. 1 p.75 ~ p.78
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Analysis of Substitution Events in HIV-1 vif Gene of the Korean Clade
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Park Chan-Seung
Kim Mi-Suk
Yi Hyun-Ah
Lee Dong-Hun
Lee Keon-Myung
Lee Chan-Hee
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Abstract
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Nucleotide and amino acid substitution pattern in vif gene of the Korean clade of HIV-1 isolated from Koreans were analyzed using consensus sequences. At nucleotide level, transition/transversion substitution ratio was 1.88, and nonsynonymous/synonymous substitution ratio was 2.67, suggesting a divergent
evolution in the Korean clade. At amino acid level, there were 17 substitutions and G→E substitution at position 37 may be responsible for change in predicted secondary structure.
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KEYWORD
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HIV-1, vif, Korean clade, substitution ratio
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