KMID : 0880420190200040662
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Korean Journal of Radiology 2019 Volume.20 No. 4 p.662 ~ p.670
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Relationship between Abnormal Hyperintensity on T2-Weighted Images Around Developmental Venous Anomalies and Magnetic Susceptibility of Their Collecting Veins: In-Vivo Quantitative Susceptibility Mapping Study
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Choi Yang-Sean
Jang Jin-Hee Nam Yoon-Ho Shin Na-Young Choi Hyun-Seok Jung So-Lyung Ahn Kook-Jin Kim Bum-Soo
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Abstract
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Objective: A developmental venous anomaly (DVA) is a vascular malformation of ambiguous clinical significance. We aimed to quantify the susceptibility of draining veins (¥övein) in DVA and determine its significance with respect to oxygen metabolism using quantitative susceptibility mapping (QSM).
Materials and Methods: Brain magnetic resonance imaging of 27 consecutive patients with incidentally detected DVAs were retrospectively reviewed. Based on the presence of abnormal hyperintensity on T2-weighted images (T2WI) in the brain parenchyma adjacent to DVA, the patients were grouped into edema (E+, n = 9) and non-edema (E?, n = 18) groups. A 3T MR scanner was used to obtain fully flow-compensated gradient echo images for susceptibility-weighted imaging with source images used for QSM processing. The ¥övein was measured semi-automatically using QSM. The normalized ¥övein was also estimated. Clinical and MR measurements were compared between the E+ and E? groups using Student's t-test or Mann-Whitney U test. Correlations between the ¥övein and area of hyperintensity on T2WI and between ¥övein and diameter of the collecting veins were assessed. The correlation coefficient was also calculated using normalized veins.
Results: The DVAs of the E+ group had significantly higher ¥övein (196.5 ¡¾ 27.9 vs. 167.7 ¡¾ 33.6, p = 0.036) and larger diameter of the draining veins (p = 0.006), and patients were older (p = 0.006) than those in the E? group. The ¥övein was also linearly correlated with the hyperintense area on T2WI (r = 0.633, 95% confidence interval 0.333?0.817, p < 0.001).
Conclusion: DVAs with abnormal hyperintensity on T2WI have higher susceptibility values for draining veins, indicating an increased oxygen extraction fraction that might be associated with venous congestion.
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KEYWORD
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Developmental venous anomaly, Quantitative susceptibility mapping, Vascular malformation, Magnetic resonance imaging
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