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KMID : 0880420200210040505
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Korean Journal of Radiology
2020 Volume.21 No. 4 p.505 ~ p.508
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False-Negative Results of Real-Time Reverse-Transcriptase Polymerase Chain Reaction for Severe Acute Respiratory Syndrome Coronavirus 2: Role of Deep-Learning-Based CT Diagnosis and Insights from Two Cases
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Li Dasheng
Wang Dawei
Dong Jianping
Wang Nana
Huang He
Xu Haiwang
Xia Chen
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Abstract
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The epidemic of 2019 novel coronavirus, later named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still gradually spreading worldwide. The nucleic acid test or genetic sequencing serves as the gold standard method for confirmation of infection, yet several recent studies have reported false-negative results of real-time reverse-transcriptase polymerase chain reaction (rRT-PCR). Here, we report two representative false-negative cases and discuss the supplementary role of clinical data with rRT-PCR, including laboratory examination results and computed tomography features. Coinfection with SARS-COV-2 and other viruses has been discussed as well.
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KEYWORD
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COVID-19, SARS-COV-2, rRT-PCR, False-negative results, Laboratory examination, Computed tomography
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