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KMID : 0880420200210070900
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Korean Journal of Radiology
2020 Volume.21 No. 7 p.900 ~ p.907
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Long-Term Clinical Effects of Carotid Intraplaque Neovascularization in Patients with Coronary Artery Disease
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Chung Hye-Moon
Kim Bu-Yong
Kim Hyun-Soo
Kim Hyung-Oh
Lee Jung-Myung
Woo Jong-Shin
Kim Jin-Bae
Kim Woo-Shik
Kim Kwon-Sam
Kim Weon
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Abstract
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Objective: To investigate the predictive value of intraplaque neovascularization (IPN) for cardiovascular outcomes.
Materials and Methods: We evaluated 217 patients with coronary artery disease (CAD) (158 men; mean age, 68 ± 10 years) with a maximal carotid plaque thickness ≥ 1.5 mm for the presence of IPN using contrast-enhanced ultrasonography. We compared patients with (n = 116) and without (n = 101) IPN during the follow-up period and investigated the predictors of major adverse cardiovascular events (MACE), including cardiac death, myocardial infarction, coronary artery revascularization, and transient ischemic accident/stroke.
Results: During the mean follow-up period of 995 ± 610 days, the MACE rate was 6% (13/217). Patients with IPN had a higher maximal thickness than those without IPN (2.86 ± 1.01 vs. 2.61 ± 0.84 mm, p = 0.046). Common carotid artery-peak systolic velocity, left ventricular mass index (LVMI), and ventricular-vascular coupling index were significantly correlated with MACE. However, on multivariate Cox regression analysis, increased LVMI was independently related to MACE (p < 0.05). The presence of IPN could not predict MACE.
Conclusion: The presence of IPN was related to a higher plaque thickness but could not predict cardiovascular outcomes better than conventional clinical factors in patients with CAD.
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KEYWORD
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Carotid intraplaque neovascularization, Contrast-enhanced ultrasound, Cardiovascular outcome
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