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KMID : 0880520150510010001
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Chonnam Medical Journal
2015 Volume.51 No. 1 p.1 ~ p.7
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Dendritic Cell-Based Cancer Immunotherapy against Multiple Myeloma: From Bench to Clinic
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Hoang My-Dung
Jung Sung-Hoon
Lee Hyun-Ju
Lee Youn-Kyung
Thanh-Nhan Nguyen-Pham
Choi Nu-Ri
Manh-Cuong Vo
Lee Seung-Shin
Ahn Jae-Sook
Yang Deok-Hwan
Kim Yeo-Kyeoung
Kim Hyeoung-Joon
Lee Je-Jung
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Abstract
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Although the introduction of stem cell transplantation and novel agents has improved survival, multiple myeloma (MM) is still difficult to cure. Alternative approaches are clearly needed to prolong the survival of patients with MM. Dendritic cell (DC) therapy is a very promising tool immunologically in MM. We developed a method to generate potent DCs with increased Th1 polarization and migration ability for inducing strong myeloma-specific cytotoxic T lymphocytes. In this review, we discuss how the efficacy of cancer immunotherapy using DCs can be improved in MM.
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KEYWORD
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Multiple myeloma, Dendritic cells, Immunotherapy
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