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KMID : 0892920130220010018
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Experimental Neurobiology
2013 Volume.22 No. 1 p.18 ~ p.22
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Memantine Reverses Social Withdrawal Induced by Ketamine in Rats
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Uribe Ezequiel
Landaeta Jose
Wix Richard
Eblen Antonio
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Abstract
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The objective of this study was to determine the effect of memantine on schizophrenia-like symptoms in a ketamine-induced social withdrawal model in rats. We examined therapeutic effects of memantine, an NMDA antagonist, and haloperidol, a classic antipsychotic drug, on this behavioral model. Administration of memantine (10 or 15 mg·kg-1) significantly reduced ketamine-induced social withdrawal, and this effect was more effective than that of haloperidol (0.25 mg·kg-1) by restoring the social interaction between rats with no modification in general motor activity. These results suggest that memantine could have a therapeutic potential for schizophrenia.
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KEYWORD
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experimental psychosis, ketamine, NMDA, haloperidol, social interaction test
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