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KMID : 0893319860010010061
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Journal of Environmental Toxicology
1986 Volume.1 No. 1 p.61 ~ p.70
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Study on the Toxicities of Polychlorinated Biphenyls, Phenol and Biphenyl
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Hong Sa-Uk
Jeong Gyu-Hyeok
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Abstract
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The effect of polychlorinated biphenyls (PCB), phenol and biphenyl on the body, liver and kidney weights, and the activity of -aminolevulinic acid dehydratase (ALAD), and the contents of microsomal cytochrome P-450, and hematocrit, TBAvalue. PCB (200 mg/kg), phenol (200 mg/kg), biphenyl (200 mg/kg), and biphenyl (100 mg/kg) added phenol (100 mg/kg) was treated orally to Sprague-Dawley rats for 3 days. In all treated groups, the body weights were decreased, while the weights of liver and kidney were increased in comparison with that of control group. The activity of -ALAD was increased and hematocrit was decreased in PCB treated group, on the contrary biphenyl treated group was appeared opposite direction. The contents of microsomal cytochrome P-450 and concentration of protein were increased in all treated group. In biphenyl treated group and phenol treated group, TBA value was increased in both groups.
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KEYWORD
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