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KMID : 0893319900050030047
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Journal of Environmental Toxicology
1990 Volume.5 No. 3 p.47 ~ p.56
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Study on the Correlation between Nicotine Concentrations in Environmental Tobacco Smoke and Urinary Cotinine Concentrations of Nonsmokers
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Roh Jin-Ho
Shin Dong-Chun
Kim Jong-Man
Chung Yong
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Abstract
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Smoking damages nonsmoker’s health who have been exposed to passive smoking as well as smoker’s own health. Passive smoking can cause serious health damage to particular groups, such as the old aged, children and pregnant women. The purpose of this study is to investigate the relationship between nicotine concentrations in environmental tobacco smoke (ETS) and urinary cotinine concentrations of nonsmokers exposed to ETS, and to provide basic information related to health risk assessment. The results of this study were summarized as follows: 1. When 180 cigarrette were smoked during S hours (high concentrations exposure) in 132 mchamber, mean concentrations of nicotine in ETS showed 263.52 /m51.93. When 45 cigarretts were smoked (low concentrations exposure), it was 69.438.96 /m. 2. The urinary cotinine concentrations of each times (0, 2.5, 5, 17 and 24 hours) in nonsmokers ranged from 0.27∼12.52 ng/ml in high concentrations exposure and 0.22∼2.28 ng/ml in low concentrations exposure. Mean while the total urinary cotinine concentrations during 24 hours ranged from 11.62∼31.65 ng/ml in high concentrations exposure and 3.45∼5.64 ng/ml in low concentrations exposure. 3. The correlation equation and coefficient between cotinine concentrations in nonsmokers’ urine (y) and nicotine concentrations in ETS (x) was y=0.421+0.0171x and 0:875 (p<0.01) respectively, 4. The quantity of nonsmokers’ smoking exposure by passive smoking can be assumed as based on the estimation of nicotine concentrations in ETS by measuring cotinine concentrations of nonsmokers’ urine.
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KEYWORD
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