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KMID : 0893319920070010042
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Journal of Environmental Toxicology
1992 Volume.7 No. 1 p.42 ~ p.51
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The Effect of Angelicae gigantis Radix on the Benzo(a)pyrene-induced Hepatotoxicity in Rats
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Yoon Soo-Hong
Cho Soo-Yeul
Lee Yun-Kyoung
Ha Do-Hyng
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Abstract
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This study was performed to investigate the effect of Angelicae gigantis Radix extract oil the hepatic detoxifying enzyme activities and lipids. Male sprague-dawley rats were administrated the extracts with benzo(a)pyrene, a hepatotoxic agent, inducing liver damages. Results obtained from this study were as follows: 1. The markedly increased enzyme activities (AST, ALT, LDH, ALP, -GTP, GSH-Px) in B(a)P induced groups tended to be decreased by the treatment of the Angelicae gigantis Radix extract. 2. Liver GSH content and lipid peroxide activity were decreased by the administration of the extracts. 3. It tended that the curative effects were better than the protective effects of the extracts.
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KEYWORD
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