|
KMID : 0893319930080030033
|
|
Journal of Environmental Toxicology
1993 Volume.8 No. 3 p.33 ~ p.41
|
|
|
Studies on the Hemolytic Mechanism of Antitumor Platinum Complex
|
|
Choi Byung-Ki
Choung Se-Young
|
|
|
Abstract
|
|
|
|
This study was designed to determine the hemolytic mechanism of antitumor agent tetraphosphine platinum (II) complex (RC-1), which was synthesized recently. Erythrocytes treated with RC-1 showed concentration and time dependent lipid peroxydation, methemoglobin synthesis and hemolysis. And also treatment of radical scavengers showed the inhibitory effect of hemolysis and the decrease of malondialdehyde levels in RC-1 treated erythrocytes. So, the mechanism of hemolysis was considered to be the generation of free radicals, methemoglobin synthesis and the lipid peroxidation of phospholipid which composed of erythrocyte membrane.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|