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KMID : 0893319950100030001
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Journal of Environmental Toxicology
1995 Volume.10 No. 3 p.1 ~ p.5
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General Toxicity of Novel Pt(II) Complexes in vivo
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Jeong Kwang-Won
Choung Se-Young
Rho Young-Soo
Lim Jong-Seok
Choi Byung-Ki
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Abstract
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The general toxicological study of new platinum(II) compounds, KHPC-002, KHPC-005 and KHPC-006 were investigated in rats. The effects of these Pt(II) complexes on renal, hematopoietic and hepatic system in rats showed lower toxicity compared with cisplatin. In the consideration of the maximal dose of these Pt(II) complexes using in this experiment is 4-8 times higher than cisplatin, these novel compounds will have the less general toxicity in vivo.
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KEYWORD
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