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KMID : 0893319960110030069
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Journal of Environmental Toxicology
1996 Volume.11 No. 3 p.69 ~ p.73
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Antilipidperoxidative Effects of Brazilin in Alloxan-induced Diabetic Mice
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An Young-Su
Khil Lee-Yong
So Dhong-Su
Chang Tong-Shin
Kim Jin-Hyoung
Moon Chang-Kiu
Park Kwang-Sik
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Abstract
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Brazilin was tested for its ability to inhibit alloxan induced lipidperoxidation. Lipid peroxide contents in liver, kidney and serum were measured by the TBA method. ICR mice receiving alloxan at a dose of 43mg/kg via the tail vein after a 24 hrs starvation showed significantly increased lipid peroxide contents as compared to untreated control. Lipid peroxide contents in liver, kidney and serum of alloxan-induced diabetic mice were dosedependently decreased by the treatment of brazilin at a dose of 10mg/kg, 50mg/kg, 100 mg/kg for 5 days.
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