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KMID : 0893319990140030103
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Journal of Environmental Toxicology
1999 Volume.14 No. 3 p.103 ~ p.111
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Estimation of Biological Action of Dioxins by Some Geometric Descriptors
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Hwang In-Chul
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Abstract
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To effectively predict the lipophilicity, the aryl hydrocarbon receptor (AhR) affinity, and TEF (Toxic equivalency factor) of dioxins by geometrical descriptors, the multiple linear regression methods with the forward selection and backward elimination were employed with statistical validity. The lipophilicity, the Ah receptor binding affinity, and the toxic equivalency factor of dioxins could be predicted using some geometrical descriptors.
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KEYWORD
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dioxin, QSAR, multiple regression, TEF, lipophilicity
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