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KMID : 0893320000150040157
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Journal of Environmental Toxicology
2000 Volume.15 No. 4 p.157 ~ p.163
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Mutagenicity of 2-[(4- Cyanophenyl)amino] -3-chloro-1, 4- naphthalenedione (NQ-Y15)
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Kim Bong-Hee
Jung Ki-Hwa
Zhang Dong-Shin
Lee Ki-Seon
Jeon Sun-Duck
So Dhong-Soo
Chae Sang-Ho
Moon Chang-Kiu
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Abstract
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2- [(4- Cyanophenyl)amino] -3-chloro-1, 4- naphthalenedione (NQ-Y15) was asssayed for its genotoxic potential by using Salmonella typhimurium reversion assay and in vitro chromosome aberration test on Chinese hamster lung cells. In the Ames test, NQ-Y15 induced his + revertants of Salmonella typhimurium TA 98 and TA1537, reaching levels twice the negative control values. But, NQ-Y15 induced only his+ revertants of Salmonella typhimurium TA1537 more than twice the control values under the condition with metabolic activation system. In the cytogenetic test on chinese hamster lung cells. NQ -Y15 showed significant chromosomal aberrations, but the incidence was significantly reduced in the presence of metabolic activation.
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KEYWORD
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2- [(4- Cyanophenyl)amino] -3-chloro-1, 4- naphthalenedione (NQ-Y15), mutagenicity, Ames test, chromosomal aberration test
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