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KMID : 0893320010160010029
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Journal of Environmental Toxicology
2001 Volume.16 No. 1 p.29 ~ p.34
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Vitellogenin mRNA Induction in Male African Clawed Frog Treated with di-2-ethylhexyl Phthalate
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Park Eung-Roh
Lee Chul-Woo
Ryu Ji-Sung
Nam Seung-Sook
Jeon Seong-Hwan
Na Jin-Gyun
Choi Doug-Il
Park Kwang-Sik
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Abstract
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The estrogenic potency of di -2-ethylhexyl phthalate (DEHP) using reverse transcriptase-PCR respouse of liver vitellogenin mRNA in male African clawed frog (Xenopus laevis) was studied. Male frogs were injected with DEHP at dose of 300/kg and 300 mg/kg body weight through the dorsal lymph sac. After 4 days, using suitable pair of RT-PCR primers, vitellogenin mRNA induction in the liver was measured and DEHP showed vitellogenin mRNA induction in only the group treated with 300 mg/kg. Any significant histological abnormalities by the exposure of DEHP was not shown in both testis and liver.
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KEYWORD
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DEHP, endocrine disruptor, Xenopus laevis, vitellogenin, RT-PCR
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