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KMID : 0893320010160040189
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Journal of Environmental Toxicology
2001 Volume.16 No. 4 p.189 ~ p.196
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Applicability of the HPLC Method for the Estimation of Octanol/water Partition Coefficient to Pesticides of Domestic Use
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Kim Kyun
Kwon Jin-Wook
Kim Yong-Hwa
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Abstract
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Octanol/water partition coefficients of 52 chemicals were calculated using RP-HPLC estimation method and predicted by computer program, PCHEM. The result showed relationship between literature values and RP-HPLC observed values (relative coefficient r＝0.916), but the relationship of PCHEM values with literature values was lower than RP-HPLC value (relative coefficient r＝0.795). The average difference in partition coefficient between the RP-HPLC method and flask-shaking method was log Kow＝0.54, while the average difference between the values predicted form the computer program and flask- shaking method was log Kow = 0.36 Compared to octanol/water partition coefficients by 3 methods (Flask-shaking, RP-HPLC, computer prediction), the octanol/water partition coefficient values based on the flask-shaking method were very similar to the literature values, while the octanol/water partition coefficient values by RP-HPLC method without to consider the dead time, and computer prediction values did not significantly differ with the literature values.
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KEYWORD
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Octanol/water partition coefficient, RP-HPLC, PCHEM, Relative coefficient, Flask-shaking, Log Kow
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