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KMID : 0893320010160040211
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Journal of Environmental Toxicology
2001 Volume.16 No. 4 p.211 ~ p.221
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Study on Inhalation Toxicity of 1-Hexene in SD Rats
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Kim Hyeon-Young
Lim Cheol-Hong
Chung Yong-Hyun
Lee Kwon-Seob
Lee Sung-Bae
Lee Jun-Yeon
Han Jeong-Hee
Lee Young-Mook
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Abstract
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The purpose of this study was to investigate the acute (4 hours) and repeated-dose (6 hours a day, 5 days a week, 4 weeks) toxic effects of 1-hexene on Sprague-Dawley (SD) rats which were treated by inhalation. The results were as follows; 1. The median lethal concentration(LC) was estimated 52,694 ppm (confidence limit 95％; 49,494~55,447 ppm) in acute inhalation. Abnormal clinical signs related to the 1-Hexene were not observed with the acute inhalation dose. Cross findings of necropsy revealed on evidence of specific toxicity related to the 1-hexene. II. By repeated inhalation exposure the body weight of male were more or less reduced by the dose of 2,500 ppm and 5,000 ppm compared with control group. However there were no significant variation hematology and blood biochemistry for the exposed rats compared with the control rats. Abnormal clinical signs and gross findings of necropsy related to the 1-hexene were not shown. In conclusion when we exposed 1-hexene to SD rats for 4 weeks, 5 days per week, 6 hours per day, the Lowest observed effect level (LOEL) was over 2,500 ppm and Non observed effect level (NOEL) was below 500 ppmpm
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KEYWORD
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Inhalation Toxicity, Acute Inhalation, Repeated Inhalation, 1-Hexene, Organic Solvents
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