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KMID : 0893320020170030261
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Journal of Environmental Toxicology
2002 Volume.17 No. 3 p.261 ~ p.264
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Antioxidant and Liver-protective Effects of Caesalpinia sappan
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Ha Hun
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Abstract
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The heartwood of Caeralpinia sappan L. (Leguminosae) has been used to activate blood flow, remove blood stasis, reduce swelling and relieve pain in Korean folk medicine. In this study. the antioxidant effects of this crude drug and its hepatoprotective activity on CCl-induced liver injury in rats were evaluated. The levels of antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT) reduced by CCltreatment, were recovered by this crude drug. It is suggested that Caesalpinia sappan L. have antioxidant effect. The increased levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) by CClwere also recovered by treatment with this crude drug. These results can be attributed to the agent’s antioxidant and membrane - stabilizing actions.
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KEYWORD
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Caesalpinia sappan L., , GOT, GPT, Superoxide dismutase, Catalase
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