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KMID : 0893320020170040307
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Journal of Environmental Toxicology
2002 Volume.17 No. 4 p.307 ~ p.314
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Effects of()-camphor on Hepatic Cytochrome P450 Enzymes in Male ICR Mice
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Oh Eun-Kyung
Park Hyung-Gun
Bae Gi-Heon
choi Ok-Jin
Choi Chang-Kun
Han Jin-Hee
Jeong Tae-Cheon
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Abstract
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Effects of ()-camphor on liver cytochrome P450 enzymes were investigated in male ICR mice. Mice were treated intraperitoneally with 0, 200, 400 and 800 mg/kg of ()-camphor in corn oil for 3 consecutive days. Twenty four hr after the final treatment, the animals were subjected to necropsy. The activities of serum aspartate aminotransferase and serum alanine aminotransferase were slightly changed by the treatment with ()-camphor at the doses used. Administration of ()-camphor to mice significantly induced the hepatic activities of pentoxyresorufin O-depentylase and benzyloxyresorufin O-debenzylase and weakly induced ethoxyresorufin O-deethylase in dose-dependent manners. The present results suggested that ()-camphor might act as a relatively specific inducer of hepatic cytochrome P450 2B in male ICR mice.
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KEYWORD
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()-Camphor, Cytochrome P450s, Induction, Male ICR mice
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