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KMID : 0893320030180020069
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Journal of Environmental Toxicology
2003 Volume.18 No. 2 p.69 ~ p.76
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Effects of Nitrite Exposure on Plasma Nitrite Levels and Hepatic Drug-metabolizing Enzymes in the Carp, Cyprinus carpio
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Park Gwan-Ha
Choi Sang-Hoon
Kim Young-Gill
Kim Yong-Ho
Choe Sun-Nam
Kim Jong-Bae
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Abstract
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Effects of ambient nitrite, NO-/, at 1, 3, 10 and 30 mg/1, on the changes of plasma nitrite/nitrate and on hepatic drug - metabolizing enzyme activity were examined in the juvenile Israeli carp, Cyprinus carpio. When the fish were exposed to 1 and 3 mg/1 NO-/, there was an exposure duration-dependent increase in plasma NO-/ over the 96-hr period reaching 6∼7 fold excess the ambient concentration. In the fish exposed to 10 mg/1, a plateau concentration of less than 2-fold of the environment was attained in 12 hr. With 30 mg/1, however, the maximal plasma NO-/ was 41.25 mg/1 at 12 hr followed by a gradual decline. There was a concentration-dependent increase in methemoglobin (metHb) level in all NO-/ -exposed groups and a significant decrease in hematocrit value in 30 mg/l group after 96-hr exposure. Apart from the blunted increase in plasma NO-/ with higher NO-/ (10 and 30 mg/1) exposure, the ratio of plasma NO-/ to NO-/ was signifirantly higher in these groups compared to 1 and 3 mg/1. The imbalance in the plasma NO-//NO-/ at higher NO-/ exposure suggests a possible accelerated conversion of NO-/ to NO-/. Nitrite exposure did not affect the hepatic drug-metabolic activities in juvenile Israeli carp. All these data indicate that disposition of NO- differ depending upon exposed concentration and that metHb production may not be the exclusive toxic mechanism in carp.
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KEYWORD
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nitrite, nitrate, israeli carp, drug-metabolizing enzymes
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