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KMID : 0893320030180030231
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Journal of Environmental Toxicology
2003 Volume.18 No. 3 p.231 ~ p.235
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Effects of Subacute Oral Administration of Bisphenol A on the IgM-PFC and Proliferation of Splenocytes in Mice
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Byun Jung-A
Pyo Myoung-Yun
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Abstract
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To determine whether or not bisphenol A affects the Immune system, female ICR mice were treated bisphenol A (BPA) orally at the doses of 100, 500 and 1,000 mg/kg for 30 consecutive days. Four days before enumerating Plaque -forming cells (PFCs) mice were immunized intraperitoneally with sheep red blood cells (SRBCs). The spleen cellularity and PFC/spleen were significantly reduced by 30-day exposure to BPA (1,000 mg/kg/day), but the PFC/106/ spleen cells was slightly decreased.. When splenocytes isolated from the mice exposed to BPA for 30 days were cultured in the presence of LPS, Con A or PHA with IL-2, the lymphocyte proliferation ex vivo was not significantly suppressed by BPA. Our present results indicated that 30-day exposure of mice to BPA might have mild immunotoxic potential.
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KEYWORD
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Bisphenol A, IgM-PFC, splenic proliferation
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