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KMID : 0893320040190030279
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Journal of Environmental Toxicology
2004 Volume.19 No. 3 p.279 ~ p.286
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The Mechanism of the Neurotoxicity Induced by Cadmium
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Lee Jong-Wha
Jang Bong-Ki
Park Jong-An
Park Jong-Young
Kim Wan-Jong
Woo Kee-Min
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Abstract
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Although numerous studies have shown that cadmium disturbs the normal biological processes in central nervous system, the mechanism of toxicity is not well understood. The present study has investigated the effect of cadmium on oxidative stress, NaK ATPase activity and the aggregation of amyloid beta peptide (-amyloid) in neuronal cell line, HT22 cell. LC and LC of cadmium for HT22 cell resulted from MTT assay was 4.1 uM and 9.5 uM, respectively. Cadmium (2 to 8 uM) dose-dependently increased the lipid peroxidation and decreased the content of glutathione. Cadmium 4 uM showed a significant decrease in Na/K ATPase activity as compared with control group. The aggregation of -amyloid was accelerated in a dose-dependent manner by the treatment with 2 to 8 uM cadmium. These results suggest that the neurotoxicity of cadmium can be mediated by the increase in oxidative stress and decrease in Na/K ATPase activity.se activity.
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KEYWORD
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cadmium, lipid peroxidation, glutathione, Na +//K +/ ATPase, -amyloid
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