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KMID : 0893320060210040323
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Journal of Environmental Toxicology
2006 Volume.21 No. 4 p.323 ~ p.330
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Toxicological Study on Nonylphenol using the Soil Nematode, Caenorhabditis elegans
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Roh Ji-Yeon
Choi Jin-Hee
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Abstract
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The aim of current study was to evaluate the toxicity of nonylphenol(NP) on soil nematode, Caenorhabditi elegans. The stress-related gene expression, growth, reproduction and development have been employed to monitor soil toxicity. The 24-h median effect concentrations of NP was . The expressions of vitellogenin-6, vitellogenin-2, cytochrome P450 family protein 35a2 and apoptosis enhancer-1 genes were upregulated in C. elegans by NP exposure. Alterations in growth, reproduction and development were also observed in NP-exposed group and especially hatching failure was observed. The overall results indicate that C. elegans has considerable potential as sensitive markers for NP toxicity monitoring.
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KEYWORD
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Caenorhabditis elegans, nonylphenol, stress-related gene expressions, growth, reproduction, development
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