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KMID : 0893320080230040301
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Journal of Environmental Toxicology
2008 Volume.23 No. 4 p.301 ~ p.306
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Effects of Carboxylethylgermanium Sesquioxide on the Cyclophosphamide-induced Immunotoxicity in Mice
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Oh Hyun-Jeong
Kim An-Keun
Yang Ki-Sook
Pyo Myoung-Yun
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Abstract
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To investigate the effects of carboxyethylgermanium sesquioxide (Ge-132) on the cyclophosphamide (CY)-induced immunotoxicity, hemagglutinin titer (HA-titer), splenic IgM plaque forming cells (PFC) and contact-delayed type hypersensitivity (CDTH) were assessed in mice. Ge-132 was orally administered alone (single dose of 300,600,900 ㎎/㎏ b.w.) or with CY (10 or 50 ㎎/㎏. i.p.) to mice on the 2nd day before. simultaneously with, the 2nd day after immunization. Within Ge-132 alone-treated groups, HA-titer and PFC to SRBC were significantly and dose-dependently enhanced when compared with control group. HA-titer and PFC numbers suppressed by the treatment of CY alone were significantly restored by the concomitant treatment of CY and Ge-132. Also, Ge-132 significantly decreased DNFB-induced CDTH and inhibited the CY-enhanced CDTH. These results indicate that Ge-132 may be able to increase humoral immunity and inhibit the immunotoxicity by CY.
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KEYWORD
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Ge-132, CY, HA-titer, PFC, CDTH
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