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KMID : 0893320090240040303
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Journal of Environmental Toxicology
2009 Volume.24 No. 4 p.303 ~ p.309
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Evaluation of Hepatic Antioxidant Defense Systems in Rats Treated with Tetrabromobisphenol-A
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Lee Sang-Yoon
Yun Kang-Uk
Park Sun-Hong
Jung Sun-Ki
Kang Keon-Wook
Jeong Tae-Cheon
Kim Hyung-Sik
Jeong Hye-Gwang
Kim Bong-Hee
Kim Sang-Kyum
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Abstract
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Hepatic antioxidant defense systems were examined in rats treated with tetrabromobisphenol-A (TBBPA), a brominated flame retardant, at the doses of 0, 250, 500 and 1,000 mg/kg for four weeks. Hepatic ratio of glutathione disulfide to glutathione (GSH) and levels of malondialdehyde, oxidative stress markers were not changed in rats treated with TBBPA. Hepatic expression of antioxidant enzymes including GSH peroxdiase-1 (GPX-1)/ GSH reductase (GR), alpha-, mu- and pi-class glutathione-S-transferase (GST) and gamma-glutamylcysteine ligase catalytic subunit was determined using immunoblot analysis. Alpha-class GSTs, GPX-1 and GR levels were significantly decreased in rats treated with TBBPA at the dose of 500 or 1,000 mg/kg. These results show that TBBPA results in down-regulation of hepatic expression of antioxidant enzymes related with GSH, suggesting the liver in TBBPA-treated rats may be more sensitive to oxidants.
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KEYWORD
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tetrabromobisphenol-A, antioxidant defense system, oxidative stress, liver
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